- Product Details
Keywords
Quick Details
- ProName: 6,7-Bis-(2-methoxyethoxy)-4(3H)-quinaz...
- CasNo: 179688-29-0
- Molecular Formula: C14H18N2O5
- Appearance: White Powder
- Application: Intermediate for Erlotinib
- DeliveryTime: Min 3 Days
- PackAge: Bag/Drum
- Port: Chengdu
- ProductionCapacity: 1 Metric Ton/Year
- Purity: 99.0%
- Storage: In Cool Place
- Transportation: Air/Sea
- LimitNum: 1 Kilogram
Superiority
Mechanism[edit] ErlotinibisanEGFRinhibitor.ThedrugfollowsIressa(gefitinib),whichwasthe&
Details
Mechanism[edit]
Erlotinib is an EGFR inhibitor. The drug follows Iressa (gefitinib), which was the first drug of this type. Erlotinib specifically targets the epidermal growth factor receptor (EGFR) tyrosine kinase, which is highly expressed and occasionally mutated in various forms of cancer. It binds in a reversible fashion to the adenosine triphosphate (ATP) binding site of the receptor.[1] For the signal to be transmitted, two EGFR molecules need to come together to form a homodimer. These then use the molecule of ATP to trans-phosphorylate each other on tyrosine residues, which generates phosphotyrosine residues, recruiting the phosphotyrosine-binding proteins to EGFR to assemble protein complexes that transduce signal cascades to the nucleus or activate other cellular biochemical processes. By inhibiting the ATP, formation of phosphotyrosine residues in EGFR is not possible and the signal cascades are not initiated.
Clinical applications[edit]
Erlotinib has shown a survival benefit in the treatment of lung cancer in phase III trials. The SATURN (Sequential Tarceva in Unresectable NSCLC) study found that erlotinib added to chemotherapy improved overall survival by 19%, and improved progression-free survival (PFS) by 29%, when compared to chemotherapy alone.[2][3] The manufacturer estimated that erlotinib can extend life by approximately 3.3 months. Some researchers call the drug "marginally" cost effective.
- Chengdu Green Young Biopharmaceutical INCTel:+86-28-85337952 Fax:+86-28-85337952 Email:greenyoung@glykj.com
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