3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline CAS NO.641571-11-1
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- Min.Order: 1 Gram
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- Available Specifications:
A(1-10)KilogramA(10-100)Kilogram
- Product Details
Keywords
- 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
- 641571-11-1
Quick Details
- ProName: 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifl...
- CasNo: 641571-11-1
- Molecular Formula: C11H10F3N3
- Appearance: White Powder
- Application: intermediate for Erlotinib
- DeliveryTime: Min 3 Days
- PackAge: Bag/Drum
- Port: Chengdu
- ProductionCapacity: 1 Metric Ton/Day
- Purity: 99.0%
- Storage: In Cool Place
- Transportation: Air/Sea
- LimitNum: 1 Gram
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Details
Nilotinib (AMN107, trade name Tasigna), in the form of the hydrochloride monohydrate salt, is a tyrosine kinase inhibitor approved for the treatment of chronic myelogenous leukemia.
Nilotinib was approved as Tasigna in the USA and the EU for drug-resistant chronic myelogenous leukemia (CML). In June 2006, a Phase I clinical trial found nilotinib has a relatively favorable safety profile and shows activity in cases of CML resistant to treatment with imatinib (trade name:Gleevec [USA]/ Glivec [Europe/Australia/Latin America]), another tyrosine kinase inhibitor currently used as a first-line treatment. In that study 92% of patients (already resistant or unresponsive to imatinib) achieved a normal white blood cell counts after five months of treatment.The drug carries a black box warning for possible heart complications.The use of low doses of nilotinib is being investigated for use for Parkinson's and Alzheimer's disease, as well as for ALS, dementiaand Huntington's disease.