Methyl 4-chloropicolinate CAS NO.24484-93-3

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Quick Details

ProName: Methyl 4-chloropicolinate
CasNo: 24484-93-3
Molecular Formula: C7H6ClNO2
Appearance: White Powder
Application: Sorafenib (co-developed and co-markete...
DeliveryTime: Min 3 Days
PackAge: bag/drum
Port: Chengdu
ProductionCapacity: 5 Metric Ton/Year
Purity: 99.0%
Storage: In cool place
Transportation: Air/Sea
LimitNum: 1 Kilogram

Superiority

Sorafenib(co-developedandco-marketedbyBayerandOnyxPharmaceuticalsasNexavar),[1]isadrugapprovedforthetreatmentofprimarykidneycancer(advancedren

Details

Sorafenib (co-developed and co-marketed by Bayer and Onyx Pharmaceuticals as Nexavar),^[1] is a drug approved for the treatment of primary kidney cancer (advanced renal cell carcinoma) and advanced primary liver cancer (hepatocellular carcinoma).

Pharmacology[edit]

Sorafenib (a bi-aryl urea^[2]) is a small molecular inhibitor of several Tyrosine protein kinases (VEGFR and PDGFR) and Raf kinases (more avidly C-Raf than B-Raf).^[3]^[4]

(Protein kinases are overactive in many of the molecular pathways that cause cells to become cancerous. These pathways include Raf kinase, PDGF (platelet-derived growth factor), VEGF receptor 2 and 3 kinases and

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